Neuropathy Nugget #4: Does the use of metformin impact thiamine (vitamin B1) utilization?

Vitamin B1 (thiamine) deficiency is a well-known cause of peripheral neuropathy.

Which of the following is true?

A. Research indicates that people on metformin are at equal risk of vitamin B1 deficiency when compared to diabetics who do not take metformin.
B. Research indicates that people on metformin are at greater risk of vitamin B1 deficiency when compared to diabetics who do not take metformin.
C. Research indicates that people on metformin are at lesser risk of vitamin B1 deficiency when compared to diabetics who do not take metformin.

Vitamine B1 deficiency, a condition which is very common in diabetics, is a well-established cause of peripheral neuropathy. Reversing vitamin B1 deficiency is an important clinical goal in the treatment of diabetic and other peripheral neuropathies.

All diabetics are at great risk of being vitamin B1 deficient. An important study published in 2007 found that plasma vitamin B1 levels were decreased by 75% in diabetics when compared with non-diabetics. The study showed that people with diabetes became vitamin B1 deficient because they urinated out vitamin B1 at rates 16 to 20 fold of non-diabetics.

The problem of vitamin B1 deficiency is compounded in diabetics on metformin. Metformin has been shown to inhibit vitamin B1 transporter molecules found in the intestines and other tissues.

The correct answer is:

B. Research indicates that people on metformin are at greater risk of vitamin B1 deficiency when compared to diabetics who do not take metformin.

Vitamin B1 deficiency causes a great many problems including, but not limited to, peripheral neuropathy, depression, problems with mental acuity, etc. The reversal of vitamin B1 deficiency is an important goal in diabetics. Benfotiamine is a high potency form of vitamin B1. It is safe, effective and acts rapidly to reverse vitamin B1 deficiency. Benfotiamine is an excellent way to restore vitamin B1 levels in people on metformin because benfotiamine is absorbed from the intestines in a manner that is not affected by the inhibition of vitamin B1 transporter molecules by metformin. Benfotiamine is the key ingredient in NeuRemedy®


Dr. Mann, Bio picture, Founder of Realm Labs, makers of NeuRemedy

This Neuropathy Nugget was authored by

Dr. Richard Mann, CEO, and Founder of Realm Labs, makers of NeuRemedy®
📱561-549-9099 |  🖥️ www.realmlabs.net.

NeuRemedy® improves the function of the nerves in the feet and legs.* NeuRemedy® is licensed by Health Canada to support the healthy function of nerves in individuals with polyneuropathy.*

Be sure to check out Neuropathy Nugget #5: Does benfotiamine improve the neurological function in alcoholics?

 

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