Which of the following is true?
1. In alcoholics, benfotiamine has been shown to improve the symptoms of polyneuropathy but not improve cognitive function.
2. In alcoholics, benfotiamine has been shown to improve cognitive function but not improve the symptoms of polyneuropathy.
3. In alcoholics, benfotiamine has been shown to improve both cognitive function and the symptoms of polyneuropathy.
4. In alcoholics, benfotiamine has been shown to have no effect on cognitive function or the symptoms of polyneuropathy.
Thiamine (Vitamin B1) deficiency is a well-known and well-documented consequence of chronic alcohol consumption. Thiamine, a water-soluble vitamin, is absorbed from the intestines primarily via the actions of thiamine transporter molecules located in the intestinal lining. These transporter molecules have been shown in animal models to be impaired by chronic alcohol exposure. Poor nutrition may be a factor, as well, in thiamine deficiency among alcoholics. Thiamine deficiency results in impaired neuronal functioning that is expressed clinically in the peripheral nervous system as polyneuropathy and in the central nervous system as deficits affecting memory and cognition.
Benfotiamine is a safe, effective, high potency, lipid soluble form of thiamine. It is absorbed from the intestines via passive diffusion, a process that does not rely on thiamine transporter molecules. As such, benfotiamine is an ideal agent to restore thiamine levels in alcoholics. Not surprisingly, it has been shown in well-constructed scientific studies to both improve the symptoms of alcoholic polyneuropathy and reduce psychiatric stress in severely affected alcoholics.
The correct answer is:
3. In alcoholics, benfotiamine has been shown to improve both cognitive function
and the symptoms of polyneuropathy.
So, when you use benfotiamine to treat a patient for alcoholic polyneuropathy you may want to ask the patient about any improvement they may have noticed in their cognitive function.
NeuRemedy® improves the function of the nerves in the feet and legs.* NeuRemedy® is licensed by Health Canada to support the healthy function of nerves in individuals with polyneuropathy.*
Be sure to check out the next Neuropathy Nugget: Is there an association between prediabetes and peripheral neuropathy?