Diabetic Polyneuropathy And Metformin

Metformin Shown to Inhibit Thiamine (Vitamin B1) Absorption, a Contributing Factor in Diabetic Polyneuropathy 

by Dr. Richard Mann, DABPS, ret, Chief Scientific Officer & Founder, Realm Labs®

In a landmark paper, Thornalley et al showed that, due to impaired kidney function, plasma thiamine levels in diabetics are 75% lower than in non-diabetics. Thiamine deficiency is a major contributing factor in the pathobiology of diabetic polyneuropathy and its reversal by a lipid soluble form of thiamine, benfotiamine,is characterized by significant improvement in the symptoms of polyneuropathy including pain, numbness and tingling of the feet and legs. Patients on metformin were recently shown to be at even greater risk of thiamine deficiency than other diabetics.  A 2015 study published in the journal Molecular Pharmacology found that metformin, the most commonly prescribed drug in the US for the treatment of diabetes, inhibited thiamine transporter molecule THTR2, decreasing thiamine absorption from the intestines and thiamine availability to peripheral neurons.

Benfotiamine is absorbed via passive diffusion.  Unlike most forms of thiamine, the absorption of benfotiamine is independent of transporter molecule THTR2.  Benfotiamine is safe, effective and works within a month.  It is ideally suited to restore thiamine levels and improve neuropathic symptoms in all diabetics, including those on metformin.

Over the past decade, benfotiamine has revolutionized the management of polyneuropathy in the US and Canada. It is currently dispensed by thousands of clinicians to their patients suffering from polyneuropathy caused by diabetes, prediabetes, alcoholism, advanced age and chemotherapy, all conditions associated with thiamine deficiency. This new data on the inhibition of thiamine absorption by metformin further explains the impressive results reported by these clinicians.


A request from the author:
Have any of your patients who have taken NeuRemedy experienced any benefits in addition to improvement in their neuropathic symptoms? If so, I would like to know. Please contact me at rhm123@gmail.com or call me at 561-549-9099.


Dr. Mann bust-shot

Dr. Richard H Mann, DABPS, ret
Chief Scientific Officer & Founder, Realm Labs

If you would like to speak with Dr. Mann about how to improve your outcomes in the treatment of polyneuropathy call 866-634-2745 or email Dr. Mann at realmlabs123@gmail.com

Dr. Mann is the developer of the  NeuRemedy®line of benfotiamine nutritional supplements. NeuRemedy is a safe, proven, and effective nutritional formulation dispensed by physicians to their patients suffering from numbness, tingling, burning and/or shooting pains in the feet and legs. These symptoms are commonly associated with diabetes, prediabetes, advanced age, chronic alcohol consumption, and chemotherapy. Thiamine (vitamin B1) deficiency often accompanies and intensifies these symptoms. The reversal of thiamine deficiency is an important therapeutic goal in the management of these patients.*

The key ingredient in NeuRemedy, benfotiamine, is the most highly bioactive oral form of thiamine available. It rapidly and safely reverses thiamine deficiency, improving the functioning of the nerves in the feet and legs. Each capsule of NeuRemedy contains 150 mg of benfotiamine in a proprietary formulation. Because of its impressive success rate and high safety profile, NeuRemedy was recently licensed in Canada as an important factor in supporting healthy nerve function in individuals with polyneuropathy.* NeuRemedy is the leader in the field with thousands of physicians and patients relying each day on its efficacy, purity, safety and rapid onset of action.*

For more information on NeuRemedy, in the USA, contact Realm Labs at 866-634-2745.
In Canada contact OHI at 855-561-4156.

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