Benfotiamine and Alzheimer’s Disease

If you are one of the thousands of physicians who use benfotiamine, a high potency lipid-soluble form of thiamine (vitamin B1), in the treatment of polyneuropathy, you are certainly aware of its beneficial effects on the functioning of neurons in the peripheral nervous system.  But a neuron is a neuron, whether in the peripheral or central nervous system, and it would be reasonable that a nutrient which improves the function of the peripheral nervous system might also improve central nervous system functioning.  This may be the case with Alzheimer’s disease.

It has long been known that Alzheimer’s disease is associated with the impairment of thiamine dependent processes in the brain.  This leads to reduced glucose metabolism and decreased energy availability to central neurons.  Research indicates that benfotiamine may prove to be beneficial for people suffering from Alzheimer’s disease.

A 2010 paper published in Brain and authored by X. Pan, et al., from the department of neurology of Shanghai Medical College, reported on the results of a study which found powerful beneficial effects on cognitive impairment with the use of benfotiamine in a mouse model of Alzheimer’s disease.  A 2016 paper authored by X. Pan, et al., in Neuroscience Bulletin reported on a study in which five patients with mild to moderate Alzheimer’s disease exhibited cognitive improvement after 18 months of receiving oral benfotiamine (300 mg daily).

A clinical trial is currently underway in the US to assess the effect of benfotiamine on Alzheimer’s disease.  The estimated study completion date is November of 2019.  Hopefully, the impressive therapeutic benefits of benfotiamine will not be limited to improving function of the peripheral nervous system and benfotiamine will, to some degree, prove helpful in the treatment of this terrible neurodegenerative disorder.

A request from the author:
Have any of your patients who have taken NeuRemedy experienced any benefits in addition to improvement in their neuropathic symptoms? If so, I would like to know. Please contact me at or call me at 561-549-9099.

Dr. Mann bust-shot

Dr. Richard H Mann, DABPS, ret
Chief Scientific Officer & Founder, Realm Labs

If you would like to speak with Dr. Mann about how to improve your outcomes in the treatment of polyneuropathy call 866-634-2745 or email Dr. Mann at

Dr. Mann is the developer of the  NeuRemedy®line of benfotiamine nutritional supplements. NeuRemedy is a safe, proven, and effective nutritional formulation dispensed by physicians to their patients suffering from numbness, tingling, burning and/or shooting pains in the feet and legs.  Thiamine (vitamin B1) deficiency often accompanies and intensifies these symptoms. The reversal of thiamine deficiency is an important therapeutic goal in the management of these patients.*

The key ingredient in NeuRemedy, benfotiamine, is the most highly bioactive oral form of thiamine available. It rapidly and safely reverses thiamine deficiency, improving the functioning of the nerves in the feet and legs. Each capsule of NeuRemedy contains 150 mg of benfotiamine in a proprietary formulation. Because of its impressive success rate and high safety profile, NeuRemedy was recently licensed in Canada as an important factor in supporting healthy nerve function in individuals with polyneuropathy.* 

NeuRemedy is the leader in the field with thousands of physicians and patients relying each day on its efficacy, purity, safety and rapid onset of action.*

For more information on NeuRemedy:
In the USA, contact Realm Labs at 866-634-2745.
In Canada contact OHI at 855-561-4156.

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