Diabetic Polyneuropathy and Benfotiamine

During episodes of hyperglycemia, unlike most other cell types, the neurons and Schwann cells of the peripheral nervous system are unable to successfully prevent the rise of their internal glucose levels and, as a consequence, are damaged. This mechanism was described by Michael Brownlee, in his seminal paper, The Pathobiology of Diabetic Complications.  Increased levels of intracellular glucose damage these cells by increasing oxidative stress and increasing flux through destructive metabolic pathways.  This results in diabetic polyneuropathy.

Benfotiamine, a high-potency, lipid-soluble form of thiamine (vitamin B1) has been shown to reduce oxidative stress, decrease flux through these destructive pathways and improve the symptoms of diabetic polyneuropathy.

Benfotiamine has also been shown to reverse thiamine deficiency, a well-established consequence of diabetes and cause of polyneuropathy. Unfortunately, the importance of thiamine deficiency in diabetes is generally underappreciated by many clinicians.  Porta et al. make the case that “diabetes might be considered a thiamine-deficient state...”. They argue that diabetes, a disease characterized by impaired carbohydrate processing, is intimately related to thiamine deficiency, a condition that impairs carbohydrate processing.

Hence, the well-established therapeutic benefits achieved with benfotiamine in the treatment of diabetic polyneuropathy are likely the result of the reduction of oxidative stress, the inhibition of destructive metabolic pathways and the reversal of thiamine deficiency in the cells of the peripheral nervous system.

Dr. Mann bust-shot

Dr. Richard H Mann, DABPS, ret
Chief Scientific Officer & Founder, Realm Labs, Makers of Nutrients to Improve the Function of the Nerves in the Feet and Legs.

This Clinical Update is brought to you by Realm Labs, the most trusted name in nutritional supplementation of nerve dysfunction in the feet and legs.

If you would like to speak with Dr. Mann about how to improve your patients with nerve dysfunction in the feet and legs, call 866-634-2745 or email Dr. Mann at realmlabs123@gmail.com.

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